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Antibodies recognizing a highly expressed putative antigen of CA-MRSA and methods of use
(United States. Patent and Trademark Office, 2012-02-28)
The present invention provides MSCRAMM® proteins from S. aureus which are putative highly-expressed antigens from methicillin-resistant S. aureus, including communit-associated MRSA (CA-MRSA), and these antigens can thus ...
Extracellular matrix-binding proteins from Staphylococcus aureus
(United States. Patent and Trademark Office, 2008-06-03)
Isolated extracellular matrix-binding proteins, designated ClfB, SdrC, SdrD and SdrE, and their corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or ...
Collagen binding protein compositions and methods of use
(United States. Patent and Trademark Office, 2001-09-11)
Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aureus, and DNA segments encoding cna from related bacteria. Also disclosed are Col binding protein (CBP) compositions and methods of ...
Method and compositions for inhibiting thrombin-induced coagulation
(United States. Patent and Trademark Office, 2004-12-28)
A method of achieving safe and effective treatment or prevention of potentially harmful blood clots, or in inhibiting the coagulation of blood when so desired such as during a wide array of disease conditions including ...
Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
(United States. Patent and Trademark Office, 2004-09-14)
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be ...
Proteins and polypeptides from coagulaslase-negative staphylococci
(United States. Patent and Trademark Office, 2009-01-06)
Proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are ...
Extracellular matrix-binding proteins from staphylococcus aureus
(United States. Patent and Trademark Office, 2004-01-20)
Isolated extracellular matrix-binding proteins, designated ClfB, SdrC, SdrD and SdrE, and their corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or ...
Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
(United States. Patent and Trademark Office, 2007-03-27)
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be ...
Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof
(United States. Patent and Trademark Office, 2012-10-02)
The present invention provides a method for determining the structure of a microbial surface components recognizing adhesive matrix molecule in complex with fibrinogen, by providing a ClfA complexed with a fibrinogen ...
Fibronectin binding protein compositions and methods of use
(United States. Patent and Trademark Office, 2004-02-03)
Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus ...