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    Extracellular matrix-binding proteins from staphylococcus aureus

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    6680195.pdf (3.454Mb)
    Date
    2004-01-20
    Author
    Patti, Joseph M.
    Foster, Timothy J.
    Josefsson, Elisabet
    Eidhin, Deidre Ni
    Hook, Magnus A. O.
    Perkins, Samuel E.
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    Abstract
    Isolated extracellular matrix-binding proteins, designated ClfB, SdrC, SdrD and SdrE, and their corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials. ClfB is a cell-wall associated protein having a predicted molecular weight of approximately 88 kDa and an apparent molecular weight of approximately 124 kDa, which binds both soluble and immobilized fibrinogen. ClfB binds both the alpha and beta chains of fibrinogen and acts as a clumping factor. SdrC, SdrD and SdrE are cell-wall associated proteins that exhibit cation-dependent ligand binding to the extracellular matrix. It has been discovered that in the A region of SdrC, SdrD, SdrE, ClfA and ClfB, there is a highly conserved amino acid sequence that can be used to derive a consensus motif of TYTFTDYVD (SEQ ID NO: 16).
    URI
    https://hdl.handle.net/1969.1/176745
    Subject
    435/320.1
    536/23.7
    C07K 14/31
    A61P 31/12
    G01N 33/56938
    G01N 2469/00
    Y10S 530/81
    Y10S 435/975
    A61K 39/00
    Y10S 530/825
    A61K 38/00
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    • Texas A&M University Patents
    Citation
    Patti, Joseph M.; Foster, Timothy J.; Josefsson, Elisabet; Eidhin, Deidre Ni; Hook, Magnus A. O.; Perkins, Samuel E. (2004). Extracellular matrix-binding proteins from staphylococcus aureus. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176745.

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