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    Collagen binding protein compositions and methods of use

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    6288214.pdf (5.147Mb)
    Date
    2001-09-11
    Author
    Hook, Magnus
    Patti, Joseph M.
    House-Pompeo, Karen
    Sthanam, Narayana
    Symersky, Jindrich
    Metadata
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    Abstract
    Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aureus, and DNA segments encoding cna from related bacteria. Also disclosed are Col binding protein (CBP) compositions and methods of use. The CBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological infections, and in particular, for use in the prevention of bacterial adhesion to Col. DNA segments encoding these proteins and anti-(Col binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of bacterial colonization in an animal such as a human. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of S. aureus infection.
    URI
    https://hdl.handle.net/1969.1/176673
    Subject
    530/387.1
    424/130.1
    424/139.1
    424/141.1
    424/150.1
    424/164.1
    424/165.1
    530/350
    530/388.1
    530/388.4
    530/389.1
    A61P 31/04
    C07K 16/1271
    C07K 14/31
    A61K 38/00
    A61K 39/00
    C07K 2317/77
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    • Texas A&M University Patents
    Citation
    Hook, Magnus; Patti, Joseph M.; House-Pompeo, Karen; Sthanam, Narayana; Symersky, Jindrich (2001). Collagen binding protein compositions and methods of use. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176673.

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