Now showing items 1-20 of 22

    • Anticancer agents and use 

      Romo, Daniel; Liu, Jun; Choi, Nam Song; Shi, Zonggao; Low, Woon-kai; Dang, Yongjun; Schneider-poetsch, Tilman (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2010-06-15)
      Provided herein are compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl ...
    • Belactosin derivatives as therapeutic agents/biological probes and their synthesis 

      Romo, Daniel; Cho, Sung Wook; Smith, Jeffrey W.; Richardson, Robyn D. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2012-02-21)
      Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, ...
    • Beta-lactone compounds 

      Smith, Jeffrey W.; Romo, Daniel; Ma, Gil; Zancanella, Manuel (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2012-09-04)
      The present invention provides compounds having the general structure A, or a pharmaceutically acceptable derivatives thereof: wherein R is an alkyl group, and R1 comprises at least one moiety selected from a group ...
    • C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers 

      Safe, Stephen S. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2012-04-03)
      The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 ?m. In addition, the ...
    • C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers 

      Safe, Stephen H. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2013-03-05)
      The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 ?m. In addition, the ...
    • Cancer treatment targeting non-coding RNA overexpression 

      Safe, Stephen; Kim, Kyounghyun (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2015-02-17)
      Provided herein are methods directed to modulating the pro-oncogenic effects of noncoding RNAs (ncRNAs) through their interactions with specificity protein transcription factors (SpTFs). In one aspect, the disclosure ...
    • Compositions and methods for drug-sensitization or inhibition of a cancer cell 

      Sacchettini, James; Zhou, Niam; Baker, Dwight; Maxwell, Steven A.; Wallis, Deeann (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2018-01-16)
      The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The ...
    • Compositions containing C-substituted diindolylmethane compounds 

      Safe, Stephen S. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2007-06-19)
      Disclosed are methods and compositions for the treatment of a wide array of cancers and tumors. In illustrative embodiments, diindolylmethanes, C-substituted diindolylmethanes, and analogs thereof have been described, which ...
    • Compounds and methods for the treatment of cancer 

      Zingaro, Ralph A.; Duzkale, Hatice; Freireich, Emil J.; Kantarjian, Hagop; Sotelo-lerma, Merida; Verstovsek, Srdan; Gao, Mingzhang (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2008-07-29)
      The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant ...
    • Compounds and methods for the treatment of cancer 

      Zingaro, Ralph A.; Zingaro, Ralph A. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2012-07-17)
      The present invention provides organic arsenicals which may be used to treat numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
    • Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers 

      Safe, Stephen H. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2010-05-04)
      Disclosed are methods and compositions for the treatment of a wide array of cancers and tumors. In illustrative embodiments, diindolylmethanes, C-substituted diindolylmethanes, and analogs thereof have been described, which ...
    • Endocrine therapy for breast cancer: combined treatment with tamoxifen plus alkyl PCDFs 

      Safe, Stephen H. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2000-10-24)
      Methods and pharmaceutical combinations for inhibiting estrogen-dependent tumors via the co-administration of antiestrogen triphenylethylenes, including tamoxifen, and alkyl PCDFs.
    • Glycyrrhetinic acid derivatives 

      Safe, Stephen H.; Chintharlapalli, Sudhakar; Mcalees, Alan; Mccrindle, Robert (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2013-03-05)
      The present invention relates to novel derivatives of glycyrrhetinic acid, compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an upregulation of PPAR&ggr ...
    • Potent immunosuppressive agents, derivatives and uses 

      Romo, Daniel; Liu, Jun; Choi, Nam Song; Shi, Zonggao; Low, Woon-kai; Dang, Yongjun; Schneider-poetsch, Tilman (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2014-09-23)
      Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and ...
    • Potent, simplified derivatives of pateamine A 

      Romo, Daniel; Liu, Jun; Choi, Nam Song; Shi, Zonggao (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2007-06-12)
      The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A—B, K, Q, X, Y, Z, R and R1 are as defined in Claim 1. The present invention ...
    • Recombinant virus expressing foreign DNA encoding feline CD86 and uses thereof 

      Winslow, Barbara J.; Cochran, Mark D.; Hash, Stephen; Choi, Insoo; Collisson, Ellen (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2007-10-09)
      The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign nucleic acid encodes a ...
    • S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer 

      Zingaro, Ralph A.; Freireich, Emil J.; Duzkale, Hatice; Kantarjian, Hagop; Verstovsek, Srdan; Sotelo-lerma, Merida (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2005-06-28)
      Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of ...
    • S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer 

      Zingaro, Ralph A.; Freireich, Emil J.; Duzkale, Hatice; Kantarjian, Hagop; Verstovsek, Srdan; Sotelo-lerma, Merida (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2009-11-17)
      Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of ...
    • S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer 

      Zingaro, Ralph A.; Freireich, Emil J.; Duzkale, Hatice; Kantarjian, Hagop; Verstovsek, Srdan; Sotelo-lerma, Merida (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2006-02-07)
      Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of ...
    • Specific binding sites in collagen for integrins and use thereof 

      Xu, Xuejun; Hook, Magnus; Kim, Jiyeun (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2009-04-07)
      The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising ...