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    S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

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    6911471.pdf (4.774Mb)
    Date
    2005-06-28
    Author
    Zingaro, Ralph A.
    Freireich, Emil J.
    Duzkale, Hatice
    Kantarjian, Hagop
    Verstovsek, Srdan
    Sotelo-lerma, Merida
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    Abstract
    Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.
    URI
    https://hdl.handle.net/1969.1/176785
    Subject
    514/504
    424/629
    556/71
    556/77
    556/78
    556/80
    C07F 9/72
    A61P 35/00
    A61P 35/02
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    • Texas A&M University Patents
    Citation
    Zingaro, Ralph A.; Freireich, Emil J.; Duzkale, Hatice; Kantarjian, Hagop; Verstovsek, Srdan; Sotelo-lerma, Merida (2005). S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176785.

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