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    Specific binding sites in collagen for integrins and use thereof

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    7514531.pdf (1.347Mb)
    Date
    2009-04-07
    Author
    Xu, Xuejun
    Hook, Magnus
    Kim, Jiyeun
    Metadata
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    Abstract
    The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction.
    URI
    http://hdl.handle.net/1969.1/176894
    Subject
    530/324
    435/7.1
    530/330
    C07K 7/06
    A61P 29/00
    G01N 33/566
    A61P 35/00
    G01N 33/6887
    C07K 14/78
    C07K 14/00
    A61P 35/04
    G01N 2500/02
    G01N 2333/78
    G01N 2333/70546
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    • Texas A&M University Patents
    Citation
    Xu, Xuejun; Hook, Magnus; Kim, Jiyeun (2009). Specific binding sites in collagen for integrins and use thereof. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from http : / /hdl .handle .net /1969 .1 /176894.

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