Browsing by Author "Watanabe, Coran"
Now showing items 1-19 of 19
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Wu, Liangxing (2010-10-12)New methodologies for the efficient syntheses of 4,4-difluoro-4-bora-3a,4adiaza- s-indacenes (BODIPYs) and rosamines were developed. A serendipitous discovery led to a new reaction which afforded BODIPYs in high yields. ...
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Reyes, Samuel Onofre J. (2009-06-02)Solid-phase syntheses of two 14-membered ring peptidomimetics were done to determine whether or not a beta-turn structure can facilitate macrocyclization. NMR methods, together with CD and QMD calculations, do not fully ...
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Exploration of the Interplay Between Allosteric Interactions of Phosphofructokinase From Rat Liver Holland III, David Alan (2018-01-17)The key metabolic enzyme phosphofructokinase (PFK) catalyzes the phosphorylation of fructose-6-phosphate (Fru-6-P) by MgATP in the first committed step of glycolysis. PFK’s phosphorylation activity is tightly regulated by ...
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Castro, Juan C. (2010-07-14)A series of fluorescein and rosamine derivatives have been prepared and their spectroscopical properties analyzed to determine their usefulness as donor and/or acceptors in "through-bond" energy transfer systems. Such new ...
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Li, Ming-Chien (2012-07-16)Two types of fluorescent molecules had been designed and synthesized to improve the analytical infrastructure of capillary electrophoretic separations. First, a hydrophilic version of the permanently cationic acridine-based ...
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Angell, Scott Edward (2009-05-15)For many years, natural products have been a primary source of new molecules for the treatment of disease, and microorganisms have been a prolific source of these molecules. Recent studies have indicated, however, that ...
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Wagner, Joshua G. (2010-01-16)The research presented provides a method to use the comparison of intermolecular isotope effects vs. the intramolecular isotope effects for the study of reactions in which study of the rate limiting step is ambiguous due ...
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Washburn, Lauren Ashley (2020-05-18)The azinomycins are hybrid nonribosomal peptide and polyketide natural products isolated from Streptomyces sahachiroi. They are of interest due to their antitumor and broad antibiotic activity, which comes from the ability ...
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Foley, Brendan (2021-01-15)The production and discovery of natural products has been a beneficial tool that provides a window into the bioorganic chemistry of organisms and offers a template for drug discovery and development. Natural products can ...
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Bench, Bennie John (2011-02-22)In recent years there have been two cycloterpenals, molecules consisting of a cyclohexadienal core, isolated from nature. Cyclocitral, the condensation product of citral, has been isolated from the North Sea bryozoans ...
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Mori, Shogo; Williams, Howard; Cagle, Davey; Karanovich, Kristopher; F. David Horgen; Smith, Roger; III; Watanabe, Coran (Marine Drugs, 2015)
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Odoi, Keturah (2012-07-16)Systematic studies of basal nonsense suppression, orthogonality of tRNAPyl variants, and cross recognition between codons and tRNA anticodons are reported. E. coli displays detectable basal amber and opal suppression but ...
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Arancillo, Maritess Noelle Victoria (2021-02-11)Small molecule probe development is pivotal in biomolecular science. Peptidomimetics are generally interesting if they resemble peptides or protein-fragments and display biological activities. To achieve this, it is desirable ...
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Franco-Torres, Francisco Miguel (2009-05-15)The pyrrole-imidazole alkaloid family of natural products illustrates the diversity of topographically unique molecules with potent biological activities that can be found in the marine environment. Thus, great interest ...
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Messer, Kayla J. (2012-07-16)The main objective of this research was to develop a protocol in which pyridoxal phosphate (PLP) would act as a tag to identify PLP-dependent enzymes from complex mixtures or cell lysates. Following the purification of a ...
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Ornelas, Argentina 1982- (2012-11-13)The Amidohydrolase Superfamily (AHS) of enzymes is one of the most structurally and functionally studied groups of biological catalysts, exquisitely designed to carry out an extensive number of reactions defined by a similar ...
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Olivard, Sarah (2012-11-28)Thiamin transport in Escherichia coli is a model system to establish the tolerance of derivatives for transport into the cell. Since little is known about what types of thiamin derivatives may be successfully taken into ...
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Zhou, Hua (2014-12-12)Drug designing usually encounters two major difficulties: construction of small molecules and target finding for the molecules. This is frustrating because either one requires tremendous effort. My research focused on how ...
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Angell, Yu Li (2009-05-15)Copper-mediated alkyne-azide cycloadditions yield 1,4-disubstituted triazoles with high chemoselectivity that can be used in many ways. For instance, when alkyne or azido peptide units combine via this pathway the reaction ...