Decorin binding protein essential peptides and methods of use
Abstract
Borrelia burgdorferi, the causative agent of Lyme disease, expresses on its surface a decorin binding protein, DbpA and DbpB. Lysine residues necessary for DbpA binding to decorin and DbpA peptides containing these critical residues essential for decorin binding are disclosed. It is further disclosed that vaccination using peptides incorporating these critical binding domains of DbpA can confer a delayed-type hypersensitivity response to DbpA and reduce the number of B. burgdorferi organisms present in infected animals.
Subject
424/185.1424/130.1
424/184.1
424/234.1
435/7.2
530/324
C07K 14/20
Y02A 50/30
Y02A 50/401
A61K 39/00
Collections
Citation
Hook, Magnus A.; Brown, Eric L. (2003). Decorin binding protein essential peptides and methods of use. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176724.