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Endocrine therapy for breast cancer: combined treatment with tamoxifen plus alkyl PCDFs
(United States. Patent and Trademark Office, 2000-10-24)
Methods and pharmaceutical combinations for inhibiting estrogen-dependent tumors via the co-administration of antiestrogen triphenylethylenes, including tamoxifen, and alkyl PCDFs.
Anticancer agents and use
(United States. Patent and Trademark Office, 2010-06-15)
Provided herein are compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl ...
Glycyrrhetinic acid derivatives
(United States. Patent and Trademark Office, 2013-03-05)
The present invention relates to novel derivatives of glycyrrhetinic acid, compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an upregulation of PPAR&ggr ...
Compounds and methods for the treatment of cancer
(United States. Patent and Trademark Office, 2008-07-29)
The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant ...
Specific binding sites in collagen for integrins and use thereof
(United States. Patent and Trademark Office, 2009-04-07)
The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising ...
Beta-lactone compounds
(United States. Patent and Trademark Office, 2012-09-04)
The present invention provides compounds having the general structure A, or a pharmaceutically acceptable derivatives thereof:
wherein R is an alkyl group, and R1 comprises at least one moiety selected from a group ...
Compositions and methods for drug-sensitization or inhibition of a cancer cell
(United States. Patent and Trademark Office, 2018-01-16)
The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The ...
S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
(United States. Patent and Trademark Office, 2005-06-28)
Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of ...
Specific binding sites in collagen for integrins and use thereof
(United States. Patent and Trademark Office, 2019-07-23)
The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising ...
Potent, simplified derivatives of pateamine A
(United States. Patent and Trademark Office, 2007-06-12)
The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A—B, K, Q, X, Y, Z, R and R1 are as defined in Claim 1. The present invention ...