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HSP20 inhibits amyloidogenesis and neurotoxicity
(United States. Patent and Trademark Office, 2014-04-29)
The present invention compositions and methods of using at least a portions of an isolated and purified α-crystallin polypeptide that includes one or more β-pleated sheets and that prevents neurotoxicity and amyloidogenesis.
Potent immunosuppressive agents, derivatives and uses
(United States. Patent and Trademark Office, 2014-09-23)
Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and ...
Tension guardrail terminal
(United States. Patent and Trademark Office, 2014-11-11)
A terminal portion of a guardrail safety system includes a terminal portion of a guardrail beam having a downstream end and upstream end. The terminal portion of the guardrail beam slopes from a height appropriate for ...
Self-assembled structures, method of manufacture thereof and articles comprising the same
(United States. Patent and Trademark Office, 2014-09-02)
Disclosed herein is a composition comprising a graft block copolymer comprising a first block polymer; the first block polymer comprising a backbone polymer and a first graft polymer; where the first graft polymer comprises ...
Plasma treatment and plasma enhanced chemical vapor deposition onto temperature sensitive biological materials
(United States. Patent and Trademark Office, 2014-12-30)
A method and apparatus for depositing a film on a biological substrate are provided. A plasma generation device includes a dielectric conduit and a high voltage electrode. The plasma generation device is placed in proximity ...
Method of treating inflammatory bowel disease by administering a clip-inducing agent
(United States. Patent and Trademark Office, 2014-12-09)
The disclosure relates to methods for treating disorders of the mucosal tract such as the gastrointestinal system by targeting CLIP molecules. The methods are based on that CLIP in the groove of MHC class I or II molecules ...
Dispersion and retrieval of de-bundled nanotubes
(United States. Patent and Trademark Office, 2014-11-25)
A method for dispersing nanotubes, comprising forming a nanocomposite solution with associated nanotubes and nanoplatelets, mixing a surfactant to the nanocomposite solution, separating the nanocomposite in solution, wherein ...
PH modulation method to detect ligand-receptor binding
(United States. Patent and Trademark Office, 2014-08-26)
The present disclosure relates to detecting receptor-ligand binding by measuring local pH modulation using a pH-sensitive fluorophore.
Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof
(United States. Patent and Trademark Office, 2014-03-04)
The present invention provides aryl- or heteroaryl-diketo acid compounds effective to inhibit an activity of a Mycobacterial malate synthase enzyme or to inhibit a malate synthase activity in other bacteria having the ...
Topological insulator-based field-effect transistor
(United States. Patent and Trademark Office, 2014-01-14)
A Topological INsulator-based field-effect transistor (TINFET) is disclosed. The TINFET includes a first and second gate dielectric layers separated by a topological insulator (TI) layer. A first gate contact is connected ...