Collagen-binding proteins from enterococcal bacteria
Abstract
A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized to inhibit adhesion of enterococcal bacteria to extracellular matrix proteins. The N-terminal region of Ace contained a region (residues 174-319), or A domain, contains several 47-residue tandem repeat units between the collagen-binding site and cell wall-associated regions. The Ace protein can be utilized in methods of preventing and/or treating enterococcal infection, and in addition, antibodies raised against Ace, or its A domain, can be used to effectively inhibit the adhesion of enterococcal cells to a collagen substrate.
Subject
424/234.1424/184.1
424/190.1
536/23.1
536/23.7
A61K 39/02
C07K 16/1275
G01N 33/56938
C07K 16/1271
A61K 2039/505
G01N 2333/315
Collections
Citation
Rich, Rebecca L.; Kriekemeyer, Bernd; Owens, Rick T.; Hook, Magnus; Murray, Barbara E.; Nallapareddy, Sreedhar R.; Weinstock, George M. (2009). Collagen-binding proteins from enterococcal bacteria. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176910.