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dc.creatorRich, Rebecca L.
dc.creatorKriekemeyer, Bernd
dc.creatorOwens, Rick T.
dc.creatorHook, Magnus
dc.creatorMurray, Barbara E.
dc.creatorNallapareddy, Sreedhar R.
dc.creatorWeinstock, George M.
dc.date.accessioned2019-06-17T17:04:29Z
dc.date.available2019-06-17T17:04:29Z
dc.date.issued2009-12-29
dc.identifier.urihttp://hdl.handle.net/1969.1/176910
dc.description.abstractA collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized to inhibit adhesion of enterococcal bacteria to extracellular matrix proteins. The N-terminal region of Ace contained a region (residues 174-319), or A domain, contains several 47-residue tandem repeat units between the collagen-binding site and cell wall-associated regions. The Ace protein can be utilized in methods of preventing and/or treating enterococcal infection, and in addition, antibodies raised against Ace, or its A domain, can be used to effectively inhibit the adhesion of enterococcal cells to a collagen substrate.en
dc.languageeng
dc.publisherUnited States. Patent and Trademark Office
dc.rightsPublic Domain (No copyright - United States)en
dc.rights.urihttp://rightsstatements.org/vocab/NoC-US/1.0/
dc.titleCollagen-binding proteins from enterococcal bacteriaen
dc.typeUtility patenten
dc.format.digitalOriginreformatted digitalen
dc.description.countryUS
dc.contributor.assigneeThe Texas A & M University System
dc.contributor.assigneeBoard of Regents of the University of Texas System
dc.identifier.patentapplicationnumber11/102757
dc.subject.uspcprimary424/234.1
dc.subject.uspcother424/184.1
dc.subject.uspcother424/190.1
dc.subject.uspcother536/23.1
dc.subject.uspcother536/23.7
dc.date.filed2005-04-11
dc.publisher.digitalTexas A&M University. Libraries


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