| dc.contributor.advisor | Kelly, Jeffrey W. | |
| dc.creator | Zacharias, Niki | |
| dc.date.accessioned | 2022-04-01T15:06:56Z | |
| dc.date.available | 2022-04-01T15:06:56Z | |
| dc.date.issued | 1997 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/CAPSTONE-ZachariasN_1997 | |
| dc.description | Program year: 1996/1997 | en |
| dc.description | Digitized from print original stored in HDR | en |
| dc.description.abstract | Dr. Jeff Kelly's laboratory has been using 4-(2-aminoethyl)-6-dibenzofuran propoinic acid an unnatural amino acid to initiate 𝛽 sheet folding. The unnatural amino acid mimics a 𝛽 tum in an antiparallel 𝛽 sheet structure. Peptides that incorporate the dibenzofuran based unnatural amino acid are being used to study the mechanism of folding and the synthesis of novel materials. A new synthesis of 4-(2-aminoethyl)-6-dibenzofuran propoinic acid has been created. The synthesis has a high yield and simple purification. The synthesis is based on the desymmetrization of the dibenzofuran ring using a monosilylation reaction. | en |
| dc.format.extent | 29 pages | en |
| dc.format.medium | electronic | en |
| dc.format.mimetype | application/pdf | |
| dc.subject | 𝛽 sheet folding | en |
| dc.subject | unnatural amino acid | en |
| dc.subject | folding | en |
| dc.subject | novel materials | en |
| dc.subject | synthesis | en |
| dc.title | Synthesis of 4-(2-aminoethyl)-6-dibenzofuran propoinic acid: An Unnatural Amino Acid that initializes B sheet Folding | en |
| dc.title.alternative | Synthesis of 4-(2-aminoethyl)-6-dibenzofuran propoinic acid: An Unnatural Amino Acid that initializes B sheet Folding | en |
| dc.type | Thesis | en |
| thesis.degree.department | Chemistry | en |
| thesis.degree.grantor | University Undergraduate Fellow | en |
| thesis.degree.level | Undergraduate | en |
| dc.type.material | text | en |
