Synthesis of 4-(2-aminoethyl)-6-dibenzofuran propoinic acid: An Unnatural Amino Acid that initializes B sheet Folding
Abstract
Dr. Jeff Kelly's laboratory has been using 4-(2-aminoethyl)-6-dibenzofuran propoinic acid an unnatural amino acid to initiate 𝛽 sheet folding. The unnatural amino acid mimics a 𝛽 tum in an antiparallel 𝛽 sheet structure. Peptides that incorporate the dibenzofuran based unnatural amino acid are being used to study the mechanism of folding and the synthesis of novel materials. A new synthesis of 4-(2-aminoethyl)-6-dibenzofuran propoinic acid has been created. The synthesis has a high yield and simple purification. The synthesis is based on the desymmetrization of the dibenzofuran ring using a monosilylation reaction.
Description
Program year: 1996/1997Digitized from print original stored in HDR
Citation
Zacharias, Niki (1997). Synthesis of 4-(2-aminoethyl)-6-dibenzofuran propoinic acid: An Unnatural Amino Acid that initializes B sheet Folding. University Undergraduate Fellow. Available electronically from https : / /hdl .handle .net /1969 .1 /CAPSTONE -ZachariasN _1997.