Automation and Lyophilization of an Injectable Polybubble Drug Delivery System

Abstract

The current state of controlled release therapeutics is limited by the challenges of: (1) developing a fabrication method that accounts for the unique sensitivities of amino acid-based cargo; and (2) designing a high-throughput drug-loading strategy that allows for both low-cost and high-resolution production of therapeutics. Addressing the above challenges will not only aid in expanding healthcare accessibility worldwide but also in optimizing the therapeutic potential of drugs. In this paper, we will report on a novel, high-throughput, automated polybubble fabrication system that seeks to address the limitations outlined above. The automated polybubble fabrication system enables polybubble production to be scaled up to meet patient demand on an industrial level, in addition to providing versatility in treatment scope. In this way, a single platform can be tailored to a variety of disease applications by allowing for loading of multiple drugs. Moreover, lyophilizing the polybubbles will allow for improved long-term stability during transport and storage, making the platform well suited for application in developing countries with limited access to medical infrastructure.