Over the Counter Liquid Bandage Application Results in Precocious Wound Closure Following Distal Amputation of the Terminal Phalangeal Digit in Mice

Abstract

CVS Liquid Bandage -- a “value brand” version of wound closure devices such as Dermabond -- following a distal, P3 amputation in mice initiates precocious wound closure; inducing a hypoxic microenvironment, and/or leading to reduced regeneration of the P3 digit. Previous research has shown that epidermal closure and a hypoxic environment are crucial in mammalian regeneration; this study looks to confirm and expand this knowledge and potentially lead to new discoveries through the use of different immunohistochemical assays: Hif1α, and Hypoxyprobe for hypoxia and EdU as a marker for cell proliferation. It is expected that the CVS Liquid Bandage will induce similar results to those produced by application of Dermabond: premature wound closure, creation of a hypoxic microenvironment, reduced degeneration and regeneration, and a similar expression pattern from the immunohistochemical assays.