Over the Counter Liquid Bandage Application Results in Precocious Wound Closure Following Distal Amputation of the Terminal Phalangeal Digit in Mice
Abstract
CVS Liquid Bandage -- a “value brand” version of wound closure devices such as Dermabond -- following a distal, P3 amputation in mice initiates precocious wound closure; inducing a hypoxic microenvironment, and/or leading to reduced regeneration of the P3 digit. Previous research has shown that epidermal closure and a hypoxic environment are crucial in mammalian regeneration; this study looks to confirm and expand this knowledge and potentially lead to new discoveries through the use of different immunohistochemical assays: Hif1α, and Hypoxyprobe for hypoxia and EdU as a marker for cell proliferation. It is expected that the CVS Liquid Bandage will induce similar results to those produced by application of Dermabond: premature wound closure, creation of a hypoxic microenvironment, reduced degeneration and regeneration, and a similar expression pattern from the immunohistochemical assays.
Citation
Tabassum, Sabeeha; Beattie, Jacob (2018). Over the Counter Liquid Bandage Application Results in Precocious Wound Closure Following Distal Amputation of the Terminal Phalangeal Digit in Mice. Undergraduate Research Scholars Program. Available electronically from https : / /hdl .handle .net /1969 .1 /188509.