Inhibitors of activin-like receptor kinases
Abstract
The claimed invention is directed to a method for screening a compound that binds to an allosteric site of ALK2, the method comprising screening for a compound that is capable of destabilizing the ALK2 protein. A further aspect of the invention is directed to a pharmaceutical composition for the treatment and/or prophylaxis of a disease in a vertebrate, said composition comprising at least one ALK receptor kinase inhibitor, and optionally a pharmaceutically acceptable carrier, adjuvant and/or diluent.
Subject
A61K 31/496A61K 31/4439
A61K 31/454
A61K 31/4545
A61K 31/473
C12Q 1/485
G01N 2333/912
G01N 2500/04
G01N 2500/20
Collections
Citation
Groppe, Jay Clemens (2018). Inhibitors of activin-like receptor kinases. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177249.