Inhibitors of activin-like receptor kinases
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The claimed invention is directed to a method for screening a compound that binds to an allosteric site of ALK2, the method comprising screening for a compound that is capable of destabilizing the ALK2 protein. A further aspect of the invention is directed to a pharmaceutical composition for the treatment and/or prophylaxis of a disease in a vertebrate, said composition comprising at least one ALK receptor kinase inhibitor, and optionally a pharmaceutically acceptable carrier, adjuvant and/or diluent.
Groppe, Jay Clemens (2018). Inhibitors of activin-like receptor kinases. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from