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    Vaccine vectors and methods of enhancing immune responses

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    8956618.pdf (1.863Mb)
    Date
    2015-02-17
    Author
    Berghman, Luc
    Bottje, Walter
    Hargis, Billy
    Layton, Sherryll
    Metadata
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    Abstract
    Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
    URI
    https://hdl.handle.net/1969.1/177092
    Subject
    424/184.1
    424/185.1
    424/186.1
    424/192.1
    424/197.11
    424/206.1
    424/234.1
    424/282.1
    424/9.2
    435/6.15
    A61P 37/04
    C12N 7/00
    A61K 39/12
    A61P 31/16
    A61K 39/145
    A61K 2039/522
    A61K 2039/543
    A61K 2039/523
    C12N 2760/16034
    A61K 2039/6006
    A61K 48/00
    A61K 2039/542
    Collections
    • Texas A&M University Patents
    Citation
    Berghman, Luc; Bottje, Walter; Hargis, Billy; Layton, Sherryll (2015). Vaccine vectors and methods of enhancing immune responses. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177092.

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