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    Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby

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    Date
    2009-11-10
    Author
    Hook, Magnus
    Xu, Yi
    Sillanpaa, Jouko V.
    Sthanam, Narayana
    Ponnuraj, Karthe
    Patti, Joseph M.
    Hutchins, Jeff T.
    Hall, Andrea
    Bowden, Maria G.
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    Abstract
    A bioinformatic method is provided for identifying and isolating proteins with MSCRAMM®—like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, which can then be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be used to generate antibodies useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
    URI
    https://hdl.handle.net/1969.1/176904
    Subject
    530/387.1
    424/130.1
    424/133.1
    424/139.1
    424/141.1
    424/150.1
    424/164.1
    435/243
    435/975
    530/388.1
    G01N 33/56911
    C07K 14/315
    C07K 16/1267
    A61P 37/04
    G01N 33/56916
    A61P 31/04
    G16B 30/00
    A61K 38/00
    Y02A 90/10
    Y02A 90/26
    G16B 15/00
    Y10S 435/975
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    • Texas A&M University Patents
    Citation
    Hook, Magnus; Xu, Yi; Sillanpaa, Jouko V.; Sthanam, Narayana; Ponnuraj, Karthe; Patti, Joseph M.; Hutchins, Jeff T.; Hall, Andrea; Bowden, Maria G. (2009). Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176904.

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