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    Fibronectin binding protein compositions and methods of use

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    7128912.pdf (6.039Mb)
    Date
    2006-10-31
    Author
    Hook, Magnus
    Patti, Joseph M.
    House-pompeo, Karen L.
    Speziale, Pietro
    Joh, Danny
    Mcgavin, Martin J.
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    Abstract
    Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus aureus, the fnbA and fnbB genes of Streptococcus dysgalactiae, and the sfb gene of Streptococcus pyogenes, and nucleic acid segments encoding these peptides and epitopes. The anti-(fibronectin binding site) antibodies, peptides and epitopes that give rise to antibodies that block the binding of fibronectin binding proteins to fibronectin, and DNA segments encoding these proteins and are of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of streptococcal and staphylococcal colonization in animals or humans. These DNA segments and the peptides derived therefrom are proposed to be of use directly in the preparation of vaccines and also for use as carrier proteins in vaccine formulations.
    URI
    http://hdl.handle.net/1969.1/176832
    Subject
    424/185.1
    424/184.1
    424/190.1
    514/9.3
    514/21.3
    514/21.4
    A61K 39/085
    A61K 39/092
    C07K 14/31
    C07K 14/315
    C07K 16/1271
    C07K 16/1275
    G01N 33/6887
    A61K 38/00
    A61K 39/00
    A61K 2039/505
    C07K 2317/34
    C07K 2317/54
    C07K 2319/00
    G01N 2333/31
    G01N 2333/315
    G01N 2333/78
    C07K 2317/76
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    • Texas A&M University Patents
    Citation
    Hook, Magnus; Patti, Joseph M.; House-pompeo, Karen L.; Speziale, Pietro; Joh, Danny; Mcgavin, Martin J. (2006). Fibronectin binding protein compositions and methods of use. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from http : / /hdl .handle .net /1969 .1 /176832.

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