Method and ophthalmic composition for treating ocular hypertension and glaucoma with butyrophenones
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Aqueous humor formation and intraocular pressure in mammals having ocular hypertension or glaucoma may be reduced by topically administering to a hypertensive eye an ophthalmologically acceptable amount of a dopamine antagonist or acid addition salt thereof. A preferred group of dopamine antagonists is the butyrophenones, especially haloperidol, trifluperidol, and moperone. An ophthalmic composition for topically treating glaucoma may comprise an aqueous solution containing 0.01% to 5% by weight of a water-soluble ophthalmologically acceptable acid addition salt of such dopamine antagonist.
Chiou, George C. Y. (1986). Method and ophthalmic composition for treating ocular hypertension and glaucoma with butyrophenones. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from