Oral immunization with transgenic plants
Abstract
The oral vaccines and oral vaccine adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogens and adjuvants when the transgenic plant material expressing the antigens is fed to animals.
Subject
536/23.7424/184.1
424/185.1
424/186.1
424/190.1
424/192.1
424/193.1
424/204.1
424/227.1
424/236.1
424/241.1
424/282.1
435/69.1
435/69.3
435/252.3
435/252.33
435/252.8
435/320.1
435/410
435/419
530/350
536/23.1
800/278
800/288
800/295
C07K 14/245
C12N 15/8258
C07K 14/005
A61P 37/02
C12N 2770/16022
A61K 39/00
Collections
Citation
Arntzen, Charles J.; Mason, Hugh S.; Haq, Tariq A. (2001). Oral immunization with transgenic plants. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176658.