dc.creator | Garfield, Robert E. | |
dc.creator | Balaban, Alexandru T. | |
dc.creator | Seitz, William A. | |
dc.creator | Klein, Douglas J. | |
dc.creator | Lesko, Melanie | |
dc.date.accessioned | 2019-06-17T16:55:00Z | |
dc.date.available | 2019-06-17T16:55:00Z | |
dc.date.issued | 1997-12-16 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/176576 | |
dc.description.abstract | Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an ortho-substituted aryl, a heteroaromatic substituent, asteroid, or a catecholamine. Preferred ortho substituents are alkoxy, halo, and alkyl. The cation of the salt is an alkali metal, an alkaline-earth metal, an ammonium or substituted ammonium group. Nitric oxide donors provided herein are more stable than that of nitrogen-bonded NONOates described previously. The by product left after release of NO, and the nitric oxide donors themselves, are very probably less carcinogenic than the corresponding nitrogen-bonded NONOates. | en |
dc.language | eng | |
dc.publisher | United States. Patent and Trademark Office | |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.title | N-nitroso-N-substituted hydroxylamines as nitric oxide donors | en |
dc.type | Utility patent | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.description.country | US | |
dc.contributor.assignee | Board of Regents, The University of Texas System | |
dc.contributor.assignee | The Texas A&M University System | |
dc.identifier.patentapplicationnumber | 08/440970 | |
dc.subject.uspcprimary | 564/112 | |
dc.subject.uspcother | 562/434 | |
dc.date.filed | 1995-05-15 | |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.subject.cpcprimary | C07C 243/06 | |
dc.subject.cpcprimary | C07D 231/38 | |
dc.subject.cpcprimary | C07D 231/38 | |
dc.subject.cpcprimary | C07D 263/48 | |
dc.subject.cpcprimary | C07D 277/50 | |
dc.subject.cpcprimary | C07D 333/36 | |