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    N-nitroso-N-substituted hydroxylamines as nitric oxide donors

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    5698738.pdf (1004Kb)
    Date
    1997-12-16
    Author
    Garfield, Robert E.
    Balaban, Alexandru T.
    Seitz, William A.
    Klein, Douglas J.
    Lesko, Melanie
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    Abstract
    Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an ortho-substituted aryl, a heteroaromatic substituent, asteroid, or a catecholamine. Preferred ortho substituents are alkoxy, halo, and alkyl. The cation of the salt is an alkali metal, an alkaline-earth metal, an ammonium or substituted ammonium group. Nitric oxide donors provided herein are more stable than that of nitrogen-bonded NONOates described previously. The by product left after release of NO, and the nitric oxide donors themselves, are very probably less carcinogenic than the corresponding nitrogen-bonded NONOates.
    URI
    http://hdl.handle.net/1969.1/176576
    Subject
    564/112
    562/434
    C07C 243/06
    C07D 231/38
    C07D 231/38
    C07D 263/48
    C07D 277/50
    C07D 333/36
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    • Texas A&M University Patents
    Citation
    Garfield, Robert E.; Balaban, Alexandru T.; Seitz, William A.; Klein, Douglas J.; Lesko, Melanie (1997). N-nitroso-N-substituted hydroxylamines as nitric oxide donors. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from http : / /hdl .handle .net /1969 .1 /176576.

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