N-nitroso-N-substituted hydroxylamines as nitric oxide donors
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Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an ortho-substituted aryl, a heteroaromatic substituent, asteroid, or a catecholamine. Preferred ortho substituents are alkoxy, halo, and alkyl. The cation of the salt is an alkali metal, an alkaline-earth metal, an ammonium or substituted ammonium group. Nitric oxide donors provided herein are more stable than that of nitrogen-bonded NONOates described previously. The by product left after release of NO, and the nitric oxide donors themselves, are very probably less carcinogenic than the corresponding nitrogen-bonded NONOates.
Garfield, Robert E.; Balaban, Alexandru T.; Seitz, William A.; Klein, Douglas J.; Lesko, Melanie (1997). N-nitroso-N-substituted hydroxylamines as nitric oxide donors. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from