| dc.contributor.advisor | Zhou, Yubin | |
| dc.creator | Liang, Yi | |
| dc.date.accessioned | 2018-09-21T15:37:01Z | |
| dc.date.available | 2018-09-21T15:37:01Z | |
| dc.date.created | 2017-12 | |
| dc.date.issued | 2017-12-12 | |
| dc.date.submitted | December 2017 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/169601 | |
| dc.description.abstract | The conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and further oxidized species is catalyzed by the Ten-eleven translocation (TET) methylcytosine dioxygenase. Here we provided a temporal control of 5mC oxidation and subsequent remodeling of epigenetic states through a split-TET2 enzyme system in mammalian cells. This chemical-inducible epigenome remodeling tool provides a precise way to interrogate cellular systems and probe the epigenotype-phenotype relations in various biological systems. | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en | |
| dc.subject | 5hmC | en |
| dc.subject | TET | en |
| dc.subject | Demethylation | en |
| dc.subject | Methylation | en |
| dc.title | Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling | en |
| dc.type | Thesis | en |
| thesis.degree.department | College of Medicine | en |
| thesis.degree.discipline | Medical Sciences | en |
| thesis.degree.grantor | Texas A & M University | en |
| thesis.degree.name | Master of Science | en |
| thesis.degree.level | Masters | en |
| dc.contributor.committeeMember | Wang, Fen | |
| dc.contributor.committeeMember | Zhu, Michael | |
| dc.contributor.committeeMember | Zhang, Dekai | |
| dc.type.material | text | en |
| dc.date.updated | 2018-09-21T15:37:04Z | |
| local.etdauthor.orcid | 0000-0003-0817-8519 | |
