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Modified lantibiotics and methods of making and using the modified lantibiotics
(United States. Patent and Trademark Office, 2020-03-03)
The subject invention pertains to a modified lantibiotic containing an intact cysteine at the C-terminus, particularly, a cysteine that is not decarboxylated and that contains a free carboxyl group. Derivatives of the ...
Modified lantibiotics and methods of making and using the modified lantibiotics
(United States. Patent and Trademark Office, 2022-01-18)
The subject invention pertains to a modified lantibiotic containing an intact cysteine at the C-terminus, particularly, a cysteine that is not decarboxylated and that contains a free carboxyl group. Derivatives of the ...
Fusion Proteins (Seldegs) For Selectively Depleting Antigen-specific Antibodies And Methods Of Use Thereof
(United States. Patent and Trademark Office, 10/4/2022)
The present disclosure includes a fusion protein, called a "Seldeg", including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at near-neutral pH, and an antigen ...
Modulators Of Melanocortin Receptors For The Treatment Of Depression And Anxiety
(United States. Patent and Trademark Office, 1/3/2023)
Compositions and methods for treating a depressive disorder or an anxiety disorder in a subject in need of such treatment are described herein. A therapeutically effective amount of a composition comprising a melanocortin ...
Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof
(United States. Patent and Trademark Office, 2021-06-22)
The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in ...