Fusion Proteins (Seldegs) For Selectively Depleting Antigen-specific Antibodies And Methods Of Use Thereof
Abstract
The present disclosure includes a fusion protein, called a "Seldeg", including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at near-neutral pH, and an antigen component fused directly or indirectly to the targeting component. The antigen component is configured to specifically bind a target antigen-specific antibody. The present disclosure also includes a method of depleting a target antigen-specific antibody from a patient by administering to the patient a Seldeg having an antigen component configured to specifically bind the target antigen-specific antibody.
Subject
C07K 16/2881C07K 14/71
C07K 2317/77
C07K 2317/92
A61K 38/00
C07K 2319/30
C07K 2317/71
C07K 2317/72
C07K 2317/52
A61K 51/1027
C07K 2317/76
C07K 2317/569
Collections
Citation
Ober, Elizabeth Sally Ward; Devanboyina, Venkata Siva Charan; Ober, Raimund Johannes (10/4). Fusion Proteins (Seldegs) For Selectively Depleting Antigen-specific Antibodies And Methods Of Use Thereof. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /197564.