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dc.contributor.advisorRees, Terry
dc.creatorKapoor, Rishika
dc.date.accessioned2017-08-21T14:38:24Z
dc.date.available2017-08-21T14:38:24Z
dc.date.created2017-05
dc.date.issued2017-04-28
dc.date.submittedMay 2017
dc.identifier.urihttp://hdl.handle.net/1969.1/161453
dc.description.abstractThis study was designed to observe the effects of an antioxidant gel on oxidative stress levels and salivary flow rates in xerostomic patients. In this prospective, nested, double blind, crossover, randomized clinical trial, unstimulated whole saliva was collected from 36 subjects, who were randomly divided into two groups: Active-Placebo (n=21) and Placebo-Active (n=15). Subjects either received the active or placebo gel for the first 4 weeks of the study and then underwent a two-week washout period between weeks 4 and 6. Subjects were then given the opposite gel product at week 6 and instructed to use this product for 4 more weeks. Salivary samples were collected at week 0,2,4,6,8,10. Statistical analysis was completed with paired t-test and mixed model analysis. Further analysis of the subset of participants with salivary flow rates below 0.200 mL/min and below 0.100 mL/min was also completed. Results indicate that oxidative stress levels did not change significantly over the course of the study in either group. Upon evaluation of participants with salivary flow rates below 0.200 mL/min, a statistically significant increase in salivary flow rate was noted in subjects in the active-placebo groups (P<.05).en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectxerostomiaen
dc.subjectantioxidantsen
dc.subjectoxidative stressen
dc.titleEffect of Antioxidant Gel on Oxidative Stress and Salivary Flow Rate in Xerostomic Patientsen
dc.typeThesisen
thesis.degree.departmentBiomedical Sciencesen
thesis.degree.disciplineOral Biologyen
thesis.degree.grantorTexas A & M Universityen
thesis.degree.nameMaster of Scienceen
thesis.degree.levelMastersen
dc.contributor.committeeMemberPlemons, Jacqueline
dc.contributor.committeeMemberRossmann, Jeffrey
dc.contributor.committeeMemberSvoboda, Kathy
dc.contributor.committeeMemberOpperman, Lynne
dc.contributor.committeeMemberCheng, Yi-Shing Lisa
dc.type.materialtexten
dc.date.updated2017-08-21T14:38:24Z
local.etdauthor.orcid0000-0002-5891-4505


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