Effect of Antioxidant Gel on Oxidative Stress and Salivary Flow Rate in Xerostomic Patients
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This study was designed to observe the effects of an antioxidant gel on oxidative stress levels and salivary flow rates in xerostomic patients. In this prospective, nested, double blind, crossover, randomized clinical trial, unstimulated whole saliva was collected from 36 subjects, who were randomly divided into two groups: Active-Placebo (n=21) and Placebo-Active (n=15). Subjects either received the active or placebo gel for the first 4 weeks of the study and then underwent a two-week washout period between weeks 4 and 6. Subjects were then given the opposite gel product at week 6 and instructed to use this product for 4 more weeks. Salivary samples were collected at week 0,2,4,6,8,10. Statistical analysis was completed with paired t-test and mixed model analysis. Further analysis of the subset of participants with salivary flow rates below 0.200 mL/min and below 0.100 mL/min was also completed. Results indicate that oxidative stress levels did not change significantly over the course of the study in either group. Upon evaluation of participants with salivary flow rates below 0.200 mL/min, a statistically significant increase in salivary flow rate was noted in subjects in the active-placebo groups (P<.05).
Kapoor, Rishika (2017). Effect of Antioxidant Gel on Oxidative Stress and Salivary Flow Rate in Xerostomic Patients. Master's thesis, Texas A & M University. Available electronically from