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dc.creatorWei, Chuanyu
dc.creatorKim, II-Kwon
dc.creatorLi, Li
dc.creatorWu, Liling
dc.creatorGupta, Sudhiranjan
dc.identifier.citationWei C, Kim I-K, Li L, Wu L, Gupta S (2014) Thymosin Beta 4 Protects Mice from Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy. PLoS ONE 9(11): e110598. doi:10.1371/journal.pone.0110598en
dc.description.abstractPulmonary hypertension (PH) is a progressive vascular disease of pulmonary arteries that impedes ejection of blood by the right ventricle. As a result there is an increase in pulmonary vascular resistance and pulmonary arterial pressure causing right ventricular hypertrophy (RVH) and RV failure. The pathology of PAH involves vascular cell remodeling including pulmonary arterial endothelial cell (PAEC) dysfunction and pulmonary arterial smooth muscle cell (PASMC) proliferation. Current therapies are limited to reverse the vascular remodeling. Investigating a key molecule is required for development of new therapeutic intervention. Thymosin beta-4 (Tβ4) is a ubiquitous G-actin sequestering protein with diverse biological function and promotes wound healing and modulates inflammatory responses. However, it remains unknown whether Tβ4 has any protective role in PH. The purpose of this study is to evaluate the whether Tβ4 can be used as a vascular-protective agent. In monocrotaline (MCT)-induced PH mouse model, we showed that mice treated with Tβ4 significantly attenuated the systolic pressure and RVH, compared to the MCT treated mice. Our data revealed for the first time that Tβ4 selectively targets Notch3-Col 3A-CTGF gene axis in preventing MCT-induced PH and RVH. Our study may provide pre-clinical evidence for Tβ4 and may consider as vasculo-protective agent for the treatment of PH induced RVH.en
dc.description.sponsorshipThe open access fee for this work was funded through the Texas A&M University Open Access to Knowledge (OAK) Fund.en
dc.rightsAttribution 3.0 United Statesen
dc.subjectPulmonary arteriesen
dc.subjectData reductionen
dc.subjectProtein expressionen
dc.subjectGene expressionen
dc.titleThymosin beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophyen
local.departmentInternal Medicineen

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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States