Browsing by Author "Zhang, Dekai"
Now showing items 1-11 of 11
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Li, Wenjiao (2017-12-06)Hepatocellular carcinoma (HCC) is the most common type of human liver cancer and it is now the second leading cause of cancer death worldwide. In the United States, its incidence has tripled since 1980 and the death rates ...
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Bai, Yan (2014-08-04)Congenital heart diseases (CHD) are the leading cause of infant mortality and morbidity. Defects of the outflow tract (OFT) make up a large percentage of human CHD. In my study, I focused on the role of Bone morphogenetic ...
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Liang, Yi (2017-12-12)The conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and further oxidized species is catalyzed by the Ten-eleven translocation (TET) methylcytosine dioxygenase. Here we provided a temporal control ...
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Tong, Yanzheng (2014-04-10)The NOD-like receptor protein NLRC5 inhibits TLR-induced NF-ҡB and viral infection-mediated type I interferon signaling in vitro. In the first project, we generated NLRC5 knockout mice to characterize the regulatory function ...
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Li, Yinyin (2014-08-06)The innate immune system is considered as the first line of host defense during infection to recognize the pathogen-associated molecular patterns (PAMPs) by several classes of germline-encoded pattern-recognition receptors ...
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Yue, Fei (2016-04-07)Autophagy is a cellular process to sequester cytoplasmic components for delivery to lysosomes for subsequent degradation, and plays important roles in aging and aging-associated pathogenesis. MAP1S is a ubiquitously ...
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Zeng, Li (2014-12-11)Breast cancer is the most commonly diagnosed cancer among American women. G-protein coupled receptors (GPCR) comprise a huge family protein with almost 800 members. GPCRs sense molecules or other stimuli outside the cell, ...
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Yue, Xiaojing (2015-04-28)In human end-stage heart failure patients, the activation of Rho kinase 1 (ROCK1) is observed in the heart. ROCK1 activation promotes the activation of caspase 3, which results in a feed-forward loop contributing to myocyte ...
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Zhao, Shu; Zhang, Yifan; Zhang, Qingyuan; Wang, Fen; Zhang, Dekai (Frontiers in Immunology, 2014)
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Zhang, Yifan (2016-11-30)Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs). The recognition leads to the activation of TLR signaling pathway, which initiates innate ...
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Fan, Yihui; Mao, Renfang; Yu, Yang; Liu, Shangfeng; Shi, Zhongcheng; Cheng, Jin; Zhang, Huiyuan; An, Lei; Zhao, Yanling; Xu, Xin; Chen, Zhenghu; Kogiso, Mari; Zhang, Dekai; Zhang, Hong; Zhang, Pumin; Jung, Jae U.; Li, Xiaonan; Xu, Guotong; Yang, Jianhua (The Journal of Experimental Medicine, 2014)