Browsing by Author "Sacchettini, James"
Now showing items 21-40 of 47
-
Najjar, Kristina (2017-07-13)For over 20 years, cell-penetrating peptides (CPPs) have been used as delivery vectors transporting macromolecules (cargos) into live cells for cell biology manipulations and therapeutic applications. While the exact ...
-
Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach Pai, Reetal; Sacchettini, James; Ioerger, Thomas (Acta Crystallographica. Section D - Biological Crystallography, 2006)
-
Wang, Feng; Langley, Robert; Gulten, Gulcin; Dover, Lynn; Besra, Gurdyal; Jacobs, William; Jr.; Sacchettini, James (The Journal of Experimental Medicine, 2007)
-
Wu, Qian (2009-05-15)Vitamin D interacting protein 205 (DRIP205) is a mediator complex protein that anchors the complex to the estrogen receptor (ER) and other nuclear receptors (NRs). In ZR-75 breast cancer cells treated with 17?-estradiol (E2) ...
-
Qu, Xiaotao (2011-02-22)Predicting protein structure using its primary sequence has always been a challenging topic in biochemistry. Although it seems as simple as finding the minimal energy conformation, it has been quite difficult to provide ...
-
Lai Hing, Steven Kenneth (2017-12-07)Natural products have long been a template by which science has produced medicines which have saved millions of lives. Bacterial sources have yielded many peptide based drugs which continue to show great value against ...
-
Martinot, Amanda J.; Farrow, Mary; Bai, Lu; Layre, Emilie; Cheng, Tan-Yun; Tsai, Jennifer H.; Iqbal, Jahangir; Annand, John W.; Sullivan, Zuri A.; Hussain, M. Mahmood; Sacchettini, James; Moody, D. Branch; Seeliger, Jessica C.; Rubin, Eric J.; Boshoff, Helena Ingrid (PLoS Pathogens, 2016)
-
Tang, Su (2018-11-02)The methylcitrate cycle and glyoxylate bypass are two critical pathways of the central carbon metabolism of the human pathogen Mycobacterium tuberculosis (Mtb). Transcription of the key enzymes in these pathways is controlled ...
-
Chintharlapalli, Sudhakar Reddy (Texas A&M University, 2007-09-17)1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes containing ptrifluoromethyl (DIM-C-pPhCF3), p-t-butyl (DIM-C-pPhtBu), and phenyl (DIM-CpPhC6H5) substituents have been identified as a new class of peroxisome ...
-
Sekar, Giridhar (2014-10-07)Membrane associating peptides such as antimicrobial peptides and viral fusion peptides are involved in a diverse set of physiological processes. Their functions often require a change in the structure of the peptide, caused ...
-
Ioerger, Thomas; Feng, Yicheng; Chen, Xiaohua; Dobos, Karen; Victor, Thomas; Streicher, Elizabeth; Warren, Robin; Nicolaas C Gey van Pittius; Paul D Van Helden; Sacchettini, James (BMC Genomics, 2010)
-
Dragset, Marte; Poce, Giovanna; Alfonso, Salvatore; Padilla-Benavides, Teresita; Ioerger, Thomas; Kaneko, Takushi; Sacchettini, James; Biava, Mariangela; Parish, Tanya; José M. Argüello; Steigedal, Magnus; Rubin, Eric (Antimicrobial Agents and Chemotherapy, 2015)
-
Kieser, Karen; Baranowski, Catherine; Chao, Michael; Long, Jarukit; Sassetti, Christopher; Waldor, Matthew; Sacchettini, James; Ioerger, Thomas; Rubin, Eric (Proceedings of the National Academy of Sciences of the United States of America, 2015)
-
Tian, Xinxin (2016-08-22)The enzyme phosphofructokinase (PFK,) catalyzes the phosphorylation of fructose-6-phosphate in the glycolysis pathway. Phosphoenolpyruvate (PEP) allosterically inhibits the binding of the substrate fructose-6-phosphate ...
-
Gomez, James; Kaufmann-Malaga, Benjamin; Wivagg, Carl; Kim, Peter; Silvis, Melanie; Renedo, Nikolai; Ioerger, Thomas; Ahmad, Rushdy; Livny, Jonathan; Fishbein, Skye; Sacchettini, James; Carr, Steven; Hung, Deborah (ELife, 2017)
-
Shepherd, Tonya Fujina (2016-08-04)Mycobacterium tuberculosis (Mtb) is the infectious agent that causes tuberculosis (Tb). In 2014, 1.5 million people succumbed to tuberculosis while an additional nine million became infected. Tuberculosis is a worldwide ...
-
Lanoix, Jean-Philippe; Ioerger, Thomas; Ormond, Aimee; Kaya, Firat; Sacchettini, James; Véronique Dartois; Nuermberger, Eric (Antimicrobial Agents and Chemotherapy, 2016)
-
Thurman, Cory Calvin (2019-03-06)The cell wall is a common component found in nearly all bacteria. Long validated as a drug target for over half of all prescribed antibiotics, it continues to offer new sources for increasing that number ever further. ...
-
Swanson, Stephanie; Ioerger, Thomas; Rigel, Nathan; Miller, Brittany; Braunstein, Miriam; Sacchettini, James (Journal of Bacteriology, 2016)
-
Kuznetsov, Vladimir 1973- (2011-08-04)Bacteriophages (phages) are viruses that infect bacteria. The phages that are described by this dissertation encompass 2 classes, double-stranded DNA phages and single-stranded RNA phages. While both of these phages ...