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    Mutacin 1140 and Occidiofungin: Natural Products Isolated from Bacterial Sources and Their Potential Applications as Therapeutics

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    LAIHING-DISSERTATION-2017.pdf (2.918Mb)
    Date
    2017-12-07
    Author
    Lai Hing, Steven Kenneth
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    Abstract
    Natural products have long been a template by which science has produced medicines which have saved millions of lives. Bacterial sources have yielded many peptide based drugs which continue to show great value against targets such as Gram-positive and Gram-negative infections. In this work, we will present two natural products yielded from Burkholderia contaminans and Streptococcus mutans bacteria which have shown great promise against multiple cancer cell lines and Gram-positive infections, respectively. B. contaminans produces occidiofungin, a non-ribosomally synthesized cyclic peptide with antifungal properties. Testing against several cancer lines, including ovarian cancer and B-cell lymphoma showed that occidiofungin had efficacy against the cancer lines at a concentration 75 times lower than cytotoxic dosing attempts in mice. S. mutans produces mutacin 1140, a lantibiotic product which is ribosomally synthesized and undergoes posttranslational modifications. We have found that in vitro dosing of mutacin 1140 in combination with an aminoglycoside, kanamycin against Staphylococcus aureus results in a synergistic inhibition effect. Both of these compounds possess great potential as therapeutics.
    URI
    https://hdl.handle.net/1969.1/169606
    Subject
    Natural products
    occidiofungin
    mutacin 1140
    lantibiotics
    antibiotic development
    Steven Lai Hin
    Leif Smith
    microbiology
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    • Electronic Theses, Dissertations, and Records of Study (2002– )
    Citation
    Lai Hing, Steven Kenneth (2017). Mutacin 1140 and Occidiofungin: Natural Products Isolated from Bacterial Sources and Their Potential Applications as Therapeutics. Doctoral dissertation, Texas A & M University. Available electronically from https : / /hdl .handle .net /1969 .1 /169606.

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