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Coordination of cell growth with cell division: G1 cyclin regulation of nitrogen metabolism
dc.creator | Bryan, Brad Allen | |
dc.date.accessioned | 2012-06-07T23:19:59Z | |
dc.date.available | 2012-06-07T23:19:59Z | |
dc.date.created | 2003 | |
dc.date.issued | 2003 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/ETD-TAMU-2003-THESIS-B79 | |
dc.description | Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item. | en |
dc.description | Includes bibliographical references (leaves 69-79). | en |
dc.description | Issued also on microfiche from Lange Micrographics. | en |
dc.description.abstract | How cell growth and metabolism are coupled with cell division is largely unknown. We examined budding yeast cells growing under continuous culture conditions, and found that cell growth requirements were not limited to the G1 phase of the cell cycle. Furthermore, the duration of cell cycle phases was different between nitrogen and glucose-limited cultures grown at the same rate. Loss of G1 cyclins, or inactivation of the cyclin-dependent kinase Cdc28p, reduced the activity of glutamate synthase, Glt1p, a key nitrogen assimilation enzyme. Jem1p, a DnaJ-type chaperone whose expression peaks at START, mediates the G1 cyclin-dependent control of Glt1p. Thus, our results establish a molecular link between START completion and control of nitrogen metabolism. | en |
dc.format.medium | electronic | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | |
dc.publisher | Texas A&M University | |
dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries in 2008. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
dc.subject | biochemistry. | en |
dc.subject | Major biochemistry. | en |
dc.title | Coordination of cell growth with cell division: G1 cyclin regulation of nitrogen metabolism | en |
dc.type | Thesis | en |
thesis.degree.discipline | biochemistry | en |
thesis.degree.name | M.S. | en |
thesis.degree.level | Masters | en |
dc.type.genre | thesis | en |
dc.type.material | text | en |
dc.format.digitalOrigin | reformatted digital | en |
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