Propionibacterium acnes as an immunostimulant
Abstract
The use of Propionibacterium acnes as an immunostimulant has been documented in various in vivo studies. Used frequently in the equine industry as a prophylactic treatment against Equine Respiratory Disease Complex (ERDC), P. acnes plays a role in activating the immune system through heightened macrophage function. While this activation is acknowledged, little is known about the specific pathway through which P. acnes act to bring about this activation. In an attempt to understand the mechanism of macrophage activation by P. acnes, studies were carried out using the macrophage cell line RAW 264.7. Treatment of RAW 264.7 cells with P. acnes in the presence of lipopolysaccharide (LPS) caused the activation of macrophages as observed by morphological changes. It also caused the induction of the inducible nitric oxide synthase (iNOS) in these cells. This induction of iNOS was dose-dependent and synergistic with LPS.
Description
Digitized from print original stored in HDR. Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.Includes bibliographical references: leaves 17-19.
Program year: 1997/1998
Subject
Propionibacterium acnesimmunostimulant
Equine Respiratory Disease Complex
macrophage activation
inducible nitric oxide synthase
lipopolysaccharide
Citation
King, Andrea L. (1998). Propionibacterium acnes as an immunostimulant. University Undergraduate Research Fellow. Available electronically from https : / /hdl .handle .net /1969 .1 /ETD -TAMU -1998 -Fellows -Thesis -K5703.