| dc.contributor.advisor | Tizard, Ian R. | |
| dc.creator | King, Andrea L. | |
| dc.date.accessioned | 2013-02-22T20:39:45Z | |
| dc.date.available | 2013-02-22T20:39:45Z | |
| dc.date.issued | 1998 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/ETD-TAMU-1998-Fellows-Thesis-K5703 | |
| dc.description | Digitized from print original stored in HDR. Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item. | en |
| dc.description | Includes bibliographical references: leaves 17-19. | en |
| dc.description | Program year: 1997/1998 | en |
| dc.description.abstract | The use of Propionibacterium acnes as an immunostimulant has been documented in various in vivo studies. Used frequently in the equine industry as a prophylactic treatment against Equine Respiratory Disease Complex (ERDC), P. acnes plays a role in activating the immune system through heightened macrophage function. While this activation is acknowledged, little is known about the specific pathway through which P. acnes act to bring about this activation. In an attempt to understand the mechanism of macrophage activation by P. acnes, studies were carried out using the macrophage cell line RAW 264.7. Treatment of RAW 264.7 cells with P. acnes in the presence of lipopolysaccharide (LPS) caused the activation of macrophages as observed by morphological changes. It also caused the induction of the inducible nitric oxide synthase (iNOS) in these cells. This induction of iNOS was dose-dependent and synergistic with LPS. | en |
| dc.format.extent | 25 pages | en |
| dc.format.medium | electronic | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en_US | |
| dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries in 2008. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
| dc.subject | Propionibacterium acnes | en |
| dc.subject | immunostimulant | en |
| dc.subject | Equine Respiratory Disease Complex | en |
| dc.subject | macrophage activation | en |
| dc.subject | inducible nitric oxide synthase | en |
| dc.subject | lipopolysaccharide | en |
| dc.title | Propionibacterium acnes as an immunostimulant | en |
| dc.type | Thesis | en |
| thesis.degree.department | Biology | en |
| thesis.degree.grantor | University Undergraduate Research Fellow | en |
| thesis.degree.name | Fellows Thesis | en |
| thesis.degree.level | Undergraduate | en |
| dc.type.material | text | en |
| dc.format.digitalOrigin | reformatted digital | en |
