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Fate of (14C)xanthotoxin (8-methoxypsoralen) in laying hens and lactating goats
dc.contributor.advisor | Ivie, G. Wayne | |
dc.creator | Pangilinan, Norma Cabanos | |
dc.date.accessioned | 2020-09-02T20:11:53Z | |
dc.date.available | 2020-09-02T20:11:53Z | |
dc.date.issued | 1990 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/DISSERTATIONS-1190556 | |
dc.description | Typescript (photocopy). | en |
dc.description.abstract | The metabolism of xanthotoxin, a naturally-occurring furanocoumarin photosensitizer, was studied in laying hens and lactating goats treated with a single oral dose equivalent to 10 mg xanthotoxin/kg of body weight. Within 48 hours, essentially all of the administered radiocarbon was eliminated in the excreta of the laying hens, while 92% and 3% were excreted in the urine and feces, respectively, of the goats. Of the different tissues collected, only the liver and blood of the laying hens; and the liver, blood, and muscle of the goats contained >.01% of the administered dose 7 days after treatment. Radiocarbon residues in the milk, egg white, egg yolk and egg shell were low. In the egg yolk and white, >95% of the radiocarbon present was identical in TLC behavior to xanthotoxin. Unmetabolized xanthotoxin, xanthotoxol, 6-(7-hydroxy-8-methoxycoumaryl)-acetic acid (HCA) and 6-(7-hydroxy-8- methoxycoumaryl)-hydroxy acetic acid (HCHA) were isolated and identified in the excreta of laying hens. Xanthotoxin is thus metabolized in the laying hens by O-demethylation, hydrolysis, and oxidation of the furan ring. In the goat, xanthotoxin is metabolized by O-demethylation, hydroxylation, reduction, oxidative cleavage of the furan ring, hydrolysis of the lactone ring, and conjugation to HCA, HCHA, xanthotoxol, 5,8-dihydroxypsoralen, psoralenquinone, 5-hydroxy-8- methoxypsoralen and 3{5-(6-hydroxy-7-methoxybenzofuryl]}-propanoic acid. | en |
dc.format.extent | xii, 152 leaves | en |
dc.format.medium | electronic | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
dc.subject | Major toxicology | en |
dc.subject.classification | 1990 Dissertation P191 | |
dc.subject.lcsh | Poultry | en |
dc.subject.lcsh | Effect of psoralens on | en |
dc.subject.lcsh | Goats | en |
dc.subject.lcsh | Effect of psoralens on | en |
dc.subject.lcsh | Photosensitization, Biological | en |
dc.title | Fate of (14C)xanthotoxin (8-methoxypsoralen) in laying hens and lactating goats | en |
dc.type | Thesis | en |
thesis.degree.grantor | Texas A&M University | en |
thesis.degree.name | Doctor of Philosophy | en |
thesis.degree.name | Ph. D | en |
dc.contributor.committeeMember | Phillips, Timothy D. | |
dc.contributor.committeeMember | Plapp, Frederick W. | |
dc.contributor.committeeMember | Safe, Stephen H. | |
dc.type.genre | dissertations | en |
dc.type.material | text | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.identifier.oclc | 24301933 |
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