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The use of single tryptophan variants to study protein folding and stability
(Texas A&M University, 2013-02-22)
Studies on the kinetics of protein folding of the histidine-containing phosphocarrier protein (HPr) from the thermophile Bacillus stearothermophilus (Bst) will contribute much to the understanding of the origins of its ...
The identification of recurrent tertiary motifs by interactions of protein secondary structure units
(Texas A&M University, 2013-02-22)
Proteins are the molecular machines that drive the processes of the cell; they carry out the functional and structural instructions outlined in an organism's genome. At their simplest, these biological catalysts are comprised ...
Investigation of electrostatics in a hydogen bond network
(Texas A&M University, 2013-02-22)
Proteins are important for many reasons -- chief among them are that many enzymes are proteins. Without enzymes, most biochemical reactions would not take place. Comparisons between proteins or amino acid sequences that ...
ASP 79 makes a large, unfavorable contribution to the conformational stability of Ribonuclease SA
(Texas A&M University, 2013-02-22)
An important unsolved problem in the field of biochemistry is the protein folding problem. Extensive research is being done to predict the structure and function of a protein given just its linear sequence of amino acids. ...
Developing a DNA vaccine to protect against brucellosis
(Texas A&M University, 2013-02-22)
Brucella are Gram-negative intracellular pathogenic bacteria, which represent a threat to human and animal health. Live vaccine strains are available to protect some animal species but no vaccines exist for human use. A ...
Using the bacteria-2-hybrid system to determine the role of S2 in the equine infectious anemia virus (EIAV) life cycle
(Texas A&M University, 2013-02-22)
After in vivo and in vitro experiments comparing wild type and S2 knockout strains of EIAV were conducted, the role of one small accessory protein still eluted discovery, S2. S2, is a small protein that has a nuclear ...
A structural investigation of the chemokine dimer interface
(Texas A&M University, 2013-02-22)
Macrophage Inflammatory Protein (MIP)-1b is a dimeric protein of the CC chemokine subfamily. Interest in both the structure and function of MIP-1b has increased rapidly over the past several years, resulting primarily from ...
Sphingosine-1-phosphate inhibits vascular smooth muscle cell migration by activating Gα₁₂ and RhoA
(Texas A&M University, 2013-02-22)
Angiogenesis, the formation of new blood vessels, is important in growth, healing, and disease. Sphingosine-1-phosphate (S1P) is a lysophospholipid with potent angiogenic effects. One of these effects is its regulation of ...
Stabilizing the cystic fibrosis transmembrane conductance regulator (CFTR) by nucleotide derivative binding to promote proper folding
(Texas A&M University, 2013-02-22)
Seventy percent of people who suffer from cystic fibrosis have a cystic fibrosis transmembrane conductance regulator gene on chromosome 7 that contains a three base-pair deletion of phenylalanine at position 508, in a ...