Browsing Colleges and Schools by Author "Sacchettini, James"
Now showing items 1-20 of 27
-
Fox, Nicholas G (2014-06-02)Iron sulfur (Fe-S) clusters are essential cofactors that function in electron transport, catalyzing substrate turnover, environmental sensing, and initiating radical chemistry. Elaborate multi-component systems have evolved ...
-
Truong, Dat Phuoc (2020-03-06)Catalytic promiscuity is the coincidental ability for an enzyme to catalyze nonbiological reactions in the same active site as the native biological reaction. Several lines of evidence show that catalytic promiscuity plays ...
-
Geng, Mengxin (2019-02-11)Lantibiotics are a class of lanthionine-containing, ribosomally synthesized and post-translationally modified peptides (RiPPs) with antimicrobial activities, and are among the most promising candidates of alternative ...
-
Wu, Fei (2009-05-15)Estrogen receptor α (ERα) is a ligand activated transcription factor. Many widely used synthetic compounds and natural chemicals can activate ERα. The compounds investigated in this study include 17β-estradiol (E2), ...
-
Vargas Bautista, Carol M (2014-08-27)The pks genes are the largest antibiotic- encoding gene cluster in Bacillus subtilis and encode the Pks enzymatic complex that produces bacillaene. Bacillaene plays important roles in the fitness of B. subtilis during ...
-
Harshbarger, Wayne (2012-10-19)Thymidylate synthase (TS), encoded by the ThyA gene, is essential for the growth and survival of Mycobacterium tuberculosis and therefore is a potential drug target. Thymidylate synthase binds both a substrate, ...
-
Mosior, John W (2021-04-07)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading cause of infectious death worldwide. In particular, the rise in incidence of drug resistant Mtb strains has made it imperative to ...
-
Ragavan, Mukundan (2014-06-27)Nuclear Magnetic Resonance (NMR) spectroscopy provides remarkable site resolution, but often requires signal averaging because of low sensitivity. Dissolution dynamic nuclear polarization (DNP), which offers large signal ...
-
Pai Karkala, Reetal (2010-07-14)Recent improvements in structural genomics efforts have greatly increased the number of hypothetical proteins in the Protein Data Bank. Several computational methodologies have been developed to determine the function of ...
-
Zhang, Chengxi (2020-07-30)In natural habitats, microorganisms synthesize specialized metabolites and enzymes that mediate chemical interactions between organisms. Those natural products have various biological activities, acting as signaling ...
-
Hughes, Ryan C (2016-12-14)Current therapies for treatment of mycobacterial infections are adequate when diagnosis and pathology is well defined. Yet more evidence is beginning to accumulate for the multitude of reasons behind drug insensitive ...
-
Wood, Jeremy Lee (2019-04-19)Combating the persistent threat and low therapeutic success of treating multidrug-resistant Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, demands a worldwide effort to discover and develop new ...
-
Najjar, Kristina (2017-07-13)For over 20 years, cell-penetrating peptides (CPPs) have been used as delivery vectors transporting macromolecules (cargos) into live cells for cell biology manipulations and therapeutic applications. While the exact ...
-
Wu, Qian (2009-05-15)Vitamin D interacting protein 205 (DRIP205) is a mediator complex protein that anchors the complex to the estrogen receptor (ER) and other nuclear receptors (NRs). In ZR-75 breast cancer cells treated with 17?-estradiol (E2) ...
-
Qu, Xiaotao (2011-02-22)Predicting protein structure using its primary sequence has always been a challenging topic in biochemistry. Although it seems as simple as finding the minimal energy conformation, it has been quite difficult to provide ...
-
Lai Hing, Steven Kenneth (2017-12-07)Natural products have long been a template by which science has produced medicines which have saved millions of lives. Bacterial sources have yielded many peptide based drugs which continue to show great value against ...
-
Tang, Su (2018-11-02)The methylcitrate cycle and glyoxylate bypass are two critical pathways of the central carbon metabolism of the human pathogen Mycobacterium tuberculosis (Mtb). Transcription of the key enzymes in these pathways is controlled ...
-
Chintharlapalli, Sudhakar Reddy (Texas A&M University, 2007-09-17)1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes containing ptrifluoromethyl (DIM-C-pPhCF3), p-t-butyl (DIM-C-pPhtBu), and phenyl (DIM-CpPhC6H5) substituents have been identified as a new class of peroxisome ...
-
Sekar, Giridhar (2014-10-07)Membrane associating peptides such as antimicrobial peptides and viral fusion peptides are involved in a diverse set of physiological processes. Their functions often require a change in the structure of the peptide, caused ...
-
Tian, Xinxin (2016-08-22)The enzyme phosphofructokinase (PFK,) catalyzes the phosphorylation of fructose-6-phosphate in the glycolysis pathway. Phosphoenolpyruvate (PEP) allosterically inhibits the binding of the substrate fructose-6-phosphate ...