High temperature ion channels and pores
Abstract
The present invention includes an apparatus, system and method for stochastic sensing of an analyte to a protein pore. The protein pore may be an engineer protein pore, such as an ion channel at temperatures above 55° C. and even as high as near 100° C. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable electrical current signal. Possible signals include change in electrical current. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may also be detected.
Subject
435/7.1204/435
422/82.01
422/82.02
435/7.2
G01N 33/48721
G01N 33/54366
G01N 33/54393
G01N 33/6872
Collections
Citation
Kang, Xiaofeng; Gu, Li Qun; Cheley, Stephen; Bayley, Hagan (2011). High temperature ion channels and pores. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176947.