Specific binding sites in collagen for integrins and use thereof
Abstract
The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction.
Subject
530/324435/7.1
530/330
C07K 7/06
A61P 29/00
G01N 33/566
A61P 35/00
G01N 33/6887
C07K 14/78
C07K 14/00
A61P 35/04
G01N 2500/02
G01N 2333/78
G01N 2333/70546
Collections
Citation
Xu, Xuejun; Hook, Magnus; Kim, Jiyeun (2009). Specific binding sites in collagen for integrins and use thereof. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176894.