142pr glass seeds for the brachytherapy of prostate cancer

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dc.contributor.advisorReece, Warren D.
dc.contributor.committeeMemberBraby, Leslie A.
dc.contributor.committeeMemberFord, John
dc.contributor.committeeMemberWalker, Michael A.
dc.creatorJung, Jae Won
dc.date.accessioned2007-09-17T19:30:44Z
dc.date.available2007-09-17T19:30:44Z
dc.date.created2003-05
dc.date.issued2007-09-17
dc.description.abstractA beta-emitting glass seed was proposed for the brachytherapy treatment of prostate cancer. Criteria for seed design were derived and several beta-emitting nuclides were examined for suitability. 142Pr was selected as the isotope of choice. Seeds 0.08 cm in diameter and 0.9 cm long were manufactured for testing. The seeds were activated in the Texas A&M University research reactor. The activity produced was as expected when considering the meta-stable state and epi-thermal neutron flux. The MCNP5 Monte Carlo code was used to calculate the quantitative dosimetric parameters suggested in the American Association of Physicists in Medicine (AAPM) TG-43/60. The Monte Carlo calculation results were compared with those from a dose point kernel code. The dose profiles agree well with each other. The gamma dose of 142Pr was evaluated. The gamma dose is 0.3 Gy at 1.0 cm with initial activity of 5.95 mCi and is insignificant to other organs. Measurements were performed to assess the 2-dimensional axial dose distributions using Gafchromic radiochromic film. The radiochromic film was calibrated using an X-ray machine calibrated against a National Institute of Standards and Technology (NIST) traceable ion chamber. A calibration curve was derived using a least squares fit of a second order polynomial. The measured dose distribution agrees well with results from the Monte Carlo simulation. The dose was 130.8 Gy at 6 mm from the seed center with initial activity of 5.95 mCi. AAPM TG-43/60 parameters were determined. The reference dose rate for 2 mm and 6 mm were 0.67 and 0.02 cGy/s/mCi, respectively. The geometry function, radial dose function and anisotropy function were generated.en
dc.format.digitalOriginborn digitalen
dc.format.extent2847451 bytesen
dc.format.mediumelectronicen
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/1969.1/5738
dc.language.isoen_US
dc.publisherTexas A&M University
dc.subjectBrachytherapyen
dc.subjectDosimetryen
dc.subjectPren
dc.subjectProstate Canceren
dc.title142pr glass seeds for the brachytherapy of prostate canceren
dc.typeBooken
dc.typeThesisen
dc.type.genreElectronic Dissertationen
dc.type.materialtexten
thesis.degree.departmentNuclear Engineeringen
thesis.degree.disciplineNuclear Engineeringen
thesis.degree.grantorTexas A&M Universityen
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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