dc.creator | Kozhina, Elena | |
dc.date.accessioned | 2010-07-15T00:15:15Z | |
dc.date.accessioned | 2010-07-23T21:46:16Z | |
dc.date.available | 2010-07-15T00:15:15Z | |
dc.date.available | 2010-07-23T21:46:16Z | |
dc.date.created | 2009-12 | |
dc.date.issued | 2010-07-14 | |
dc.date.submitted | December 2009 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7419 | |
dc.description.abstract | In Drosophila, XX embryos express Sxl from the early promoter, SxlPe, and
become females. At the same time, XY embryos with only one X chromosome become
males.
I investigated the role of repression in the establishment of the strict regulation of
SxlPe. I found that the co-repressor Groucho, is responsible for amplification of the
two-fold difference in X-encoded activator genes into an all-or-nothing difference in Sxl
expression. Three new basic helix-loop-helix repressors of Sxl were identified: Hey,
Cwo and the prooncogene Myc, all of which are maternally supplied. I have shown that
Myc specific repression is important as early as cycle 10, which is 2 cycles earlier than
the onset of normal Sxl expression. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.subject | Drosophila | en |
dc.subject | promoter | en |
dc.subject | repressor | en |
dc.subject | Groucho | en |
dc.subject | Sxl | en |
dc.subject | Hey | en |
dc.subject | Cwo | en |
dc.subject | Myc. | en |
dc.title | Role of Repressors in Fine Regulation of Development: Sxl and Its New Repressors Hey and Myc | en |
dc.type | Book | en |
dc.type | Thesis | en |
thesis.degree.department | Biology | en |
thesis.degree.discipline | Genetics | en |
thesis.degree.grantor | Texas A&M University | en |
thesis.degree.name | Master of Science | en |
thesis.degree.level | Masters | en |
dc.contributor.committeeMember | Erickson, James W. | |
dc.contributor.committeeMember | Bell-Pedersen, Deborah | |
dc.contributor.committeeMember | Carney, Ginger E. | |
dc.contributor.committeeMember | Maggert, Keith A. | |
dc.type.genre | Electronic Thesis | en |
dc.type.material | text | en |