Show simple item record

dc.contributor.advisorChen, Jianer
dc.contributor.advisorSze, Sing-Hoi
dc.creatorLu, Songjian
dc.date.accessioned2010-07-15T00:14:36Z
dc.date.accessioned2010-07-23T21:45:45Z
dc.date.available2010-07-15T00:14:36Z
dc.date.available2010-07-23T21:45:45Z
dc.date.created2009-12
dc.date.issued2010-07-14
dc.date.submittedDecember 2009
dc.identifier.urihttps://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7222
dc.description.abstractParameterized NP-hard problems are NP-hard problems that are associated with special variables called parameters. One example of the problem is to find simple paths of length k in a graph, where the integer k is the parameter. We call this problem the p-path problem. The p-path problem is the parameterized version of the well-known NP-complete problem - the longest simple path problem. There are two main reasons why we study parameterized NP-hard problems. First, many application problems are naturally associated with certain parameters. Hence we need to solve these parameterized NP-hard problems. Second, if parameters take only small values, we can take advantage of these parameters to design very effective algorithms. If a parameterized NP-hard problem can be solved by an algorithm of running time in form of f(k)nO(1), where k is the parameter, f(k) is independent of n, and n is the input size of the problem instance, we say that this parameterized NP-hard problem is fixed parameter tractable (FPT). If a problem is FPT and the parameter takes only small values, the problem can be solved efficiently (it can be solved almost in polynomial time). In this dissertation, first, we introduce several techniques that can be used to design efficient algorithms for parameterized NP-hard problems. These techniques include branch and bound, divide and conquer, color coding and dynamic programming, iterative compression, iterative expansion and kernelization. Then we present our results about how to use these techniques to solve parameterized NP-hard problems, such as the p-path problem and the pd-feedback vertex set problem. Especially, we designed the first algorithm of running time in form of f(k)nO(1) for the pd-feedback vertex set problem. Thus solved an outstanding open problem, i.e. if the pd-feedback vertex set problem is FPT. Finally, we will introduce how to use parameterized algorithm techniques to solve the signaling pathway problem and the motif finding problem from bioinformatics.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.subjectAlgorithm, parameterized NP-hard problems, fixed parameter tractable, Directed feedback back vertex set problem, bioinformaticsen
dc.titleRandomized and Deterministic Parameterized Algorithms and Their Applications in Bioinformaticsen
dc.typeBooken
dc.typeThesisen
thesis.degree.departmentComputer Science and Engineeringen
thesis.degree.disciplineComputer Scienceen
thesis.degree.grantorTexas A&M Universityen
thesis.degree.nameDoctor of Philosophyen
thesis.degree.levelDoctoralen
dc.contributor.committeeMemberButenko, Sergiy
dc.contributor.committeeMemberFriesen, Donald
dc.type.genreElectronic Dissertationen
dc.type.materialtexten


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record