Impact of dorsolateral periaqueductal gray lesions on shock-induced hyperalgesia
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Prior exposure to shock lowers vocalization thresholds to heat and facilitates the acquisition of conditioned fear when training is conducted in a difference context. These observations have been taken as evidence that shock exposure increases the effective impact of subsequent aversive stimuli, a phenomenon known as hyperalgesia. The present study explores whether this hyperalgesia depends on neurons within the dorsolateral periaqueductal gray (d1PAG). Experiment 1 showed that lesioning either the rostral or caudal diPAG prevented the shock-induced reduction in vocalization thresholds. Experiment 2 showed those lesioned subjects also failed to exhibit facilitated learning after shock exposure. Taken together, these results suggest that the diPAG play a critical role in the production of shock-induced hyperalgesia.
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Includes bibliographical references: leaves 23-26.
McLemore, Sherilyn (1998). Impact of dorsolateral periaqueductal gray lesions on shock-induced hyperalgesia. Texas A&M University. Available electronically from