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Identification and partial sequence of a chicken beta-adrenergic receptor
dc.creator | Wright, William Waggoner | |
dc.date.accessioned | 2012-06-07T22:43:26Z | |
dc.date.available | 2012-06-07T22:43:26Z | |
dc.date.created | 1995 | |
dc.date.issued | 1995 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/ETD-TAMU-1995-THESIS-W76 | |
dc.description | Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item. | en |
dc.description | Includes bibliographical references. | en |
dc.description | Issued also on microfiche from Lange Micrographics. | en |
dc.description.abstract | Epinephrine and other related catecholamines activate adrenergic receptors to affect cell chemistry through second messenger cascades. Beta (0) adrenergic receptors couple with GTP-binding proteins (G proteins) to modulate the adenylate cyclase cascade. 0-adrenergic receptors have a seven-helix motif that displays sequence homology across diverse species. However, receptor diversity is apparent, especially at the carboxyl end, between mammals and turkeys, the only recorded sequence from aves. These differences could explain the different growth responses to []-adrenergic agonists observed between mammals and aves. The Polymerase Chain Reaction (PCR) was used to amplify and sequence the chicken 0-adrenergic receptor using PCR primers extrapolated from the turkey sequence. The PCR product was cloned to produce a 400 base pair probe for the chicken. The probe was hybridized with a Leghorn chicken library to isolate the chicken P-adrenergic receptor sequence, and positive clones were analyzed by automated sequencing. | en |
dc.format.medium | electronic | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | |
dc.publisher | Texas A&M University | |
dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries in 2008. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
dc.subject | genetics. | en |
dc.subject | Major genetics. | en |
dc.title | Identification and partial sequence of a chicken beta-adrenergic receptor | en |
dc.type | Thesis | en |
thesis.degree.discipline | genetics | en |
thesis.degree.name | M.S. | en |
thesis.degree.level | Masters | en |
dc.type.genre | thesis | en |
dc.type.material | text | en |
dc.format.digitalOrigin | reformatted digital | en |
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