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Characterization of genetic resistance to helminths in goats using microsatellite genetic markers
|dc.creator||Kogi, Joseph Kan'gethe|
|dc.description||Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to firstname.lastname@example.org, referencing the URI of the item.||en|
|dc.description||Includes bibliographical references.||en|
|dc.description.abstract||Twenty-four microsatellite markers, isolated from caprine and bovine genomic libraries were used to genotype DNA collected from the Kenya dual purpose goat (KDPG) flock. Two hundred and eighty-one animals with eggs per gram of feces (EPG) and packed cell volume (PCV) as measures of haemonchosis, were used in an analysis to detect associations with the m-icrosatellite markers. SAS GLM was used to fit a fixed effects model that included year of birth, season of birth, sex of the kid, type of birth, breed of kid, sire within breed of kid, haplotype within sire within breed of kid, and age of dam as a covariate. PCV and EPG were statistically associated with four microsatellite markers. Markers SR-CRSP-I and SR-CRSP-12 were associated with PCV and markers SR-CRSP-II and TEXAN-2 were associated with EPG. The same model was used to determine marker association with birth weight, weaning weight, weight at 6, 9, and 12 months and coccidial egg counts. Marker SR-CRSP-14 was found to be significantly associated with birthweight. Markers SR-CRSP- I 1, SRCRSP-16, SR-CRSP-18, and SR-CRSP-20 were associated with weaning weight. SR-CRSP-1 I was also associated with weaning weight, weight at 6 months, and EPG. Weight at 9 months was associated with SR-CRSP-3 and SR-CRSP-20. Microsatellite markers SR-CRSP-2 and SR-CRSP-3 were determined to be linked with a lod-score of 3.1 1, a recombination rate of 18%, and an estimated distance of 18.3 map units which was consistent with earlier results obtained in similar analyses.||en|
|dc.publisher||Texas A&M University|
|dc.rights||This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries in 2008. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use.||en|
|dc.subject||Major animal breeding.||en|
|dc.title||Characterization of genetic resistance to helminths in goats using microsatellite genetic markers||en|
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