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Biomolecules containing the SAsR₂ functional group : a chemical and carcinostatic study
dc.contributor.advisor | Zingaro, Ralph A. | |
dc.creator | Mitchell, Cheryl Ruth | |
dc.date.accessioned | 2020-09-02T21:11:18Z | |
dc.date.available | 2020-09-02T21:11:18Z | |
dc.date.issued | 1980 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/DISSERTATIONS-778839 | |
dc.description | Vita. | en |
dc.description.abstract | Thio sugar and thio steroid esters of several dialkylarsinous acids have been prepared and characterized. Specifically, the syntheses of the following compounds have been investigated: 1-thio-2,3:5,6-di-O-isopropylidene mannofuranose; 1-S-dialkylarsino-1-thio-2,3:5,6-di-O-isopropylidene-mannofuranoside, (alkyl = methyl, ethyl, propyl, and butyl); 6-thio-1,2,3,4-tetra-O-acetyl-mannopyranoside; 6-S-alkylarsino-6-thio-1,2,3,4-tetra-O-acetyl-mannopyranoside, (alkyl = methyl, ethyl, propyl, and butyl); 3-thio-dehydroisoandrosterone; 3-S-dialkylarsino-3-thio-dehydroisoandrosterone, (alkyl = methyl, ethyl, propyl, and butyl); Pregn-4-ene-1,16-dithio-21-acetyl-3,11,20 trione; Pregna-1,4-diene-16-S-dialkylarsino-16-thio-21-acetyl-3,11,20-trione, (alkyl = methyl, ethyl); 24-thio-lanosterol; 24-S-dialkylarsino-24-thio lanosterol, (alkyl = methyl, ethyl). Attempted preparations are also reported for 17-S-dialkylarsino-17-thio-testosterone and 17-S-dialkylarsino-17-thio-cortisone acetate. The [^1}H NMR spectrum of these compounds may be interpreted in a manner consistent with the proposed structures. [^13]C NMR spectra were reported and used to elucidate the structure of the dehydroisoandrosterol. The mass spectra of the compounds are reported... | en |
dc.format.extent | xiii, 230 leaves | en |
dc.format.medium | electronic | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
dc.subject | Major chemistry | en |
dc.subject.classification | 1980 Dissertation M681 | |
dc.subject.lcsh | Antineoplastic agents | en |
dc.subject.lcsh | Mannose | en |
dc.title | Biomolecules containing the SAsR₂ functional group : a chemical and carcinostatic study | en |
dc.type | Thesis | en |
thesis.degree.grantor | Texas A&M University | en |
thesis.degree.name | Doctor of Philosophy | en |
dc.contributor.committeeMember | Bates, G. W. | |
dc.contributor.committeeMember | Hall, M. B. | |
dc.contributor.committeeMember | Meyers, Edward A. | |
dc.type.genre | dissertations | en |
dc.type.material | text | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.identifier.oclc | 6894968 |
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