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The effect of selected six-mercaptopurine metallo complexes upon purine metabolism in normal and tumor-bearing rats
| dc.contributor.advisor | Lewis, R. W. | |
| dc.creator | Skinner, Sheri Melody | |
| dc.date.accessioned | 2020-08-21T22:13:32Z | |
| dc.date.available | 2020-08-21T22:13:32Z | |
| dc.date.issued | 1980 | |
| dc.identifier.uri | https://hdl.handle.net/1969.1/DISSERTATIONS-676194 | |
| dc.description | Vita. | en |
| dc.description.abstract | The research described in this dissertation concerns the investigation of selected 6-mercaptopurine metallo complexes. Syntheses are developed, the compounds are screened for anti-carcinogenic activity in two in vivo leukemia systems and then are tested for their effects upon the activity of adenosine deaminase (E.C. 3.5.4.4) in rat tissues. A colorimetric assay is used, complemented by an enzyme peak-shift procedure using reversed-phase high pressure liquid chromatography. Treatment with these drugs is found to have no effect upon the activity of this enzyme in selected rat tissues. | en |
| dc.format.extent | ix, 88 leaves | en |
| dc.format.medium | electronic | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | |
| dc.rights | This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. | en |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
| dc.subject | Major biochemistry | en |
| dc.subject.classification | 1980 Dissertation S628 | |
| dc.subject.lcsh | Immunosuppressive agents | en |
| dc.subject.lcsh | Antineoplastic agents | en |
| dc.subject.lcsh | Purines | en |
| dc.subject.lcsh | Metabolism | en |
| dc.subject.lcsh | Enzymatic analysis | en |
| dc.subject.lcsh | Organometallic compounds | en |
| dc.subject.lcsh | Rats | en |
| dc.subject.lcsh | Physiology | en |
| dc.title | The effect of selected six-mercaptopurine metallo complexes upon purine metabolism in normal and tumor-bearing rats | en |
| dc.type | Thesis | en |
| thesis.degree.grantor | Texas A&M University | en |
| thesis.degree.name | Doctor of Philosophy | en |
| dc.contributor.committeeMember | Landmann, W. A. | |
| dc.contributor.committeeMember | MacFarlane, R. D. | |
| dc.contributor.committeeMember | Sis, R. F. | |
| dc.type.genre | dissertations | en |
| dc.type.material | text | en |
| dc.format.digitalOrigin | reformatted digital | en |
| dc.publisher.digital | Texas A&M University. Libraries | |
| dc.identifier.oclc | 6749537 |
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